Karmic Dice - yes or no?

Somewhere during the Early Access Larian introduced the loaded / Karmic dice, to even out extreme effects of dice rolls. In EA this was enabled at default, and I assume the same will be true for the final release. It feels like it is a less pure D&D feature, since D&D gameplay is based on die rolls.

What do you think? Play with or without the Karmic Dice option enabled? And why?